Olive Leaf Extract

Olive Leaf and Full Spectrum Healing:

1. Oleuropein in Olive and its Pharmacological Effects: “The present review focuses on recent works that have analyzed the relationship between the major phenolic compound oleuropein and its pharmacological activities including antioxidant, anti-inflammatory, anti-atherogenic, anti-cancer activities, antimicrobial activity, antiviral activity, hypolipidemic and hypoglycemic effect.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002804

Olive Leaf and High Blood Pressure:

1. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension comparison with Captopril: “In conclusion, Olive (Olea europaea) leaf extract, at the dosage regimen of 500 mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5-25 mg twice daily.”  http://www.ncbi.nlm.nih.gov/pubmed/21036583

2. A clinical trial of a titrated Olea extract in the treatment of essential arterial hypertension:  “We note for all patients a statistically significant decrease of blood pressure.” http://www.ncbi.nlm.nih.gov/pubmed/8786521

3. Blood pressure lowering effect of an olive leaf extract (Olea europaea)… “The findings confirm previous reports on the hypotensive (lowering of blood pressure) effects of olive leaf.” http://www.ncbi.nlm.nih.gov/pubmed/12489249

4. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins: “Concluding, the study confirmed the antihypertensive and cholesterol-lowering action of EFLA943 (olive leaf extract) in humans.” http://www.ncbi.nlm.nih.gov/pubmed/18729245

5. Olive Leaf Safely Modulates Blood Pressure: http://www.lifeextension.com/magazine/2012/3/olive-leaf-safely-modulates-blood-pressure/page-01

Olive Leaf and Viruses, Bacteria and Fungal Infections:

1. The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV): “Therefore, we propose that O. europaea could be used as a potential source of promising natural antivirals, which have demonstrated to lack impact on health and environment. In addition, Ole could be used to design other related antiviral agents.” http://www.ncbi.nlm.nih.gov/pubmed/15869811

2.  Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment: “We investigated the antiviral activity of olive leaf extract (OLE) preparations standardized by liquid chromatography-coupled mass spectrometry (LC-MS) against HIV-1 infection and replication. We find that OLE inhibits acute infection and cell-to-cell transmission of HIV-1 as assayed by syncytia formation using uninfected MT2 cells co-cultured with HIV-1-infected H9 T lymphocytes. OLE also inhibits HIV-1 replication as assayed by p24 expression in infected H9 cells… Treatment with OLE reverses many of these HIV-1 infection-associated changes. Treatment of HIV-1-infected cells with OLE also up-regulates the expression of the apoptosis inhibitor proteins IAP1 and 2, as well as the calcium and protein kinase C pathway signaling molecules IL-2, IL-2Ralpha, and ornithine decarboxylase ODC1.” http://www.ncbi.nlm.nih.gov/pubmed/12878215

3. In vitro antimicrobial activity of olive leaves: “We investigated the antimicrobial effect of olive leaves against bacteria and fungi. The microorganisms tested were inoculated in various concentrations of olive leaf water extract. Olive leaf 0.6% (w/v) water extract killed almost all bacteria tested, within 3 hours.” http://www.ncbi.nlm.nih.gov/pubmed/12870202

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